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It is not known whether Glucovance will harm an unborn babySimilar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of deliveryTell your doctor if you are pregnant or plan to become pregnant.

Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformine.gorganic cationic transport-2OCT2multidrug and toxin extrusionMATEinhibitors such as ranolazinevandetanibdolutegravirand cimetidinecould increase systemic exposure to metformin and may increase the accumulation of metformin and the risk for lactic acidosisConsider the benefits and risks of concomitant useSuch interaction between metformin and oral cimetidine has been observed in normal healthy volunteers in both singleand multiple-dosemetformin-cimetidine drug interaction studieswith a 60increase in peak metformin plasma and whole blood concentrations and a 40increase in plasma and whole blood metformin AUCThere was no change in elimination half-life in the single-dose studyMetformin had no effect on cimetidine pharmacokinetics.

Take the medicine as soon as you canbut skip the missed dose if it is almost time for your next doseDo not take two doses at one time.

Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refillIf you have any questionsask your doctor or pharmacist.

Rarelytoo much metformin can build up in the body and cause a serioussometimes fatalcondition called lactic acidosisLactic acidosis is more likely if you are an older adultif you have kidney or liver diseasedehydrationheart failureheavy alcohol useif you have surgeryif you have X-ray or scanning procedures that use iodinated contrastor if you are using certain drugsFor some conditionsyour doctor may tell you to stop taking this medication for a short timeAsk your doctor or pharmacist for more details.

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